By Kolio D. Troev
Phosphonic acid esters are intermediates within the synthesis of vital sessions of compounds comparable to alpha-aminophosphonic acids, bisphosphonates, epoxyalkylphosphonates, alpha-hydroxyalkylphosphonates, phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of every of those compound sessions is reviewed in detail.
Alpha-Aminophosphonic acids are a major category of biologically energetic compounds, that have acquired an expanding quantity of cognizance simply because they're thought of to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphonates as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic brokers are good documented. Alpha-Hydroxyalkanephosphonates are compounds of important organic and medicinal purposes. Dialkyl epoxyalkylphosphonates are of curiosity as a result of their use as intermediates within the synthesis of bioactive ingredients, and as modifiers of ordinary and artificial polymers. Bisphosphonates are medicinal drugs which have been usual in numerous bone illnesses, and feature lately been used effectively opposed to many parasites. Poly(alkylene H-phosphonate)s and poly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of substances. Nucleoside H-phosphonates appear to be the main appealing applicants as beginning fabrics within the chemical synthesis of DNA and RNA fragments. The 5’-hydrogen phosphonate-3’-azido-2’,3’-dideoxythimidine is among the most vital anti-HIV prodrug, that is presently in medical trials.
Chapters evaluate the synthesis; actual and spectral houses (1H, 13C, 31P and 17O NMR data); attribute reactions; vital sessions of compounds in line with those esters of H-phosphonic acid; their software as physiologically energetic ingredients, flame retardants, catalysts, warmth and light stabilizers, lubricants, scale inhibitors, polymer-carriers of medications; training of H-phosphonate diesters and normal systems for engaging in crucial reactions.
* offers rules for the synthesis of phosphonates, phosphoramides and diesters of phosphonic acid (new phosphorus-containing compounds)
* studies constitution, spectra and organic task of H-phosphonates and their derivatives
* examines new parts of program of phosphorus-containing compounds
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Chemistry and Application of H-Phosphonates by Kolio D. Troev